A.B. 1963 University of California, Berkeley
(The major subject for all degrees was Statistics.)
My interests regarding research are in statistics and mathematics and
their applications to medicine and biology. Many efforts have concerned
binary tree-structured algorithms for classification, regression,
survival analysis, and clustering. Those for classification and
survival analysis have been used with success in computer-aided diagnosis
and prognosis, especially in cardiology, oncology, and toxicology.
With the late Leo Breiman, Jerome Friedman (of Stanford), and Charles Stone
(of the University of California, Berkeley) I coauthored the book
Classification and Regression Trees, that gives motivation, algorithms,
various examples, and mathematical theory for what have come to be known as
CART algorithms. The approaches to tree-structured clustering have been applied
to lossy data compression, especially in digital radiography
Robert Gray of the Department of Electrical Engineering at Stanford and others),
and also to HIV genetics. Recent research concerns applying information on SNPs
(single nucleotide polymorphisms) and other features as together they predispose to
hypertension in a population of white women.
Much of my work concerns analyses of longitudinal data. Some that
was of interest concerned the pharmacokinetics of intracavitary
chemotherapy with systemic rescue. Related efforts have also been
to the development of mature walking, longitudinal studies of cholesterol,
and many aspects of glomerular filtration in patients with nephrotic disorders.
With the late David Sutherland, Edmund Biden, and Marilynn Wyatt I coauthored
The Development of Mature Walking.
Some research has involved more mathematical problems, including those that
arise concerning exchangeable probabilities, conditional levels of particular
test statistics, topological category regarding CART-like estimators in
regression, and successive standardization of rectangular arrays of numbers.